dsu functions in a MYO5A-independent pathway to suppress the coat color of dilute mice.

@article{OSullivan2004dsuFI,
  title={dsu functions in a MYO5A-independent pathway to suppress the coat color of dilute mice.},
  author={ToolkitJoseph O'Sullivan and Xufeng Wu and Rivka A. Rachel and J Huang and Deborah A. Swing and Lydia E. Matesic and John A Hammer and Neal G. Copeland and Nancy A. Jenkins},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 48},
  pages={16831-6}
}
MYO5A is a major actin-based vesicle transport motor that binds to one of its cargos, the melanosome, by means of a RAB27A/MLPH receptor. When one of the members of this receptor-motor complex is mutated, the melanosomes clump in the perinuclear region of the melanocyte and are transferred unevenly to the developing hair, leading to a dilution of coat color. Mutation of a fourth gene, dilute suppressor (dsu), suppresses this coat color dilution. MYO5A is required for the peripheral accumulation… CONTINUE READING