deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes.

@article{King2003deltaNp63alphaFA,
  title={deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes.},
  author={Kathryn E. King and Roshini M. Ponnamperuma and Toshiharu Yamashita and Takashi Tokino and Lela A. Lee and Marian Francis Young and Wendy C. Weinberg},
  journal={Oncogene},
  year={2003},
  volume={22 23},
  pages={3635-44}
}
deltaNp63 is overexpressed in squamous carcinomas where it is associated with proliferation and is believed to enhance cell growth by blocking p53-mediated transactivation. In normal epithelium, deltaNp63alpha protein expression is abundant in basal cells and decreases with differentiation. To explore the biological consequences of deltaNp63alpha overexpression in relation to squamous carcinogenesis, we evaluated its effect on normal squamous differentiation and p53 transactivation function in… CONTINUE READING
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