decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo

@article{Ferguson1992decapentaplegicAA,
  title={decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo},
  author={Edwin L. Ferguson and Kathryn V Anderson},
  journal={Cell},
  year={1992},
  volume={71},
  pages={451-461}
}
Zygotic expression of the Drosophila TGF beta family member decapentaplegic (dpp) is required for the development of the dorsal embryonic structures. By injecting dpp transcripts into young embryos, we find that 2- to 4-fold increases in the concentration of injected RNA elicit progressively more dorsal cell fates: only low levels of dpp permit development of ventral ectoderm, intermediate dpp levels drive dorsal epidermal development, and high dpp levels drive cells to differentiate as the… CONTINUE READING
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