decapentaplegic Is Essential for the Maintenance and Division of Germline Stem Cells in the Drosophila Ovary

@article{Xie1998decapentaplegicIE,
  title={decapentaplegic Is Essential for the Maintenance and Division of Germline Stem Cells in the Drosophila Ovary},
  author={T. Xie and A. Spradling},
  journal={Cell},
  year={1998},
  volume={94},
  pages={251-260}
}
Stem cells are thought to occupy special local environments, or niches, established by neighboring cells that give them the capability for self-renewal. Each ovariole in the Drosophila ovary contains two germline stem cells surrounded by a group of differentiated somatic cells that express hedgehog and wingless. Here we show that the BMP2/4 homolog decapentaplegic (dpp) is specifically required to maintain female germline stem cells and promote their division. Overexpression of dpp blocks… Expand
Bam and Bgcn in Drosophila germline stem cell differentiation.
Asymmetric Stem Cell Division and function of the Niche in the Drosophila Male Germ Line
COP9-Hedgehog axis regulates the function of the germline stem cell progeny differentiation niche in the Drosophila ovary
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