decapentaplegic Is Essential for the Maintenance and Division of Germline Stem Cells in the Drosophila Ovary

@article{Xie1998decapentaplegicIE,
  title={decapentaplegic Is Essential for the Maintenance and Division of Germline Stem Cells in the Drosophila Ovary},
  author={Ting Xie and Allan C. Spradling},
  journal={Cell},
  year={1998},
  volume={94},
  pages={251-260}
}
Stem cells are thought to occupy special local environments, or niches, established by neighboring cells that give them the capability for self-renewal. Each ovariole in the Drosophila ovary contains two germline stem cells surrounded by a group of differentiated somatic cells that express hedgehog and wingless. Here we show that the BMP2/4 homolog decapentaplegic (dpp) is specifically required to maintain female germline stem cells and promote their division. Overexpression of dpp blocks… Expand
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