decapentaplegic Is Essential for the Maintenance and Division of Germline Stem Cells in the Drosophila Ovary

  title={decapentaplegic Is Essential for the Maintenance and Division of Germline Stem Cells in the Drosophila Ovary},
  author={T. Xie and A. Spradling},
  • T. Xie, A. Spradling
  • Published 1998
  • Biology, Medicine
  • Cell
  • Stem cells are thought to occupy special local environments, or niches, established by neighboring cells that give them the capability for self-renewal. Each ovariole in the Drosophila ovary contains two germline stem cells surrounded by a group of differentiated somatic cells that express hedgehog and wingless. Here we show that the BMP2/4 homolog decapentaplegic (dpp) is specifically required to maintain female germline stem cells and promote their division. Overexpression of dpp blocks… CONTINUE READING

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