de recherche Responsiveness of 5-HT 1 A and 5-HT 2 receptors in the rat orbitofrontal cortex after long-term serotonin reuptake inhibition


Rev Psychiatr Neurosci 2005;30(4) © 2005 CMA Media Inc. Background: The only antidepressant drugs that are effective in the treatment of obsessive–compulsive disorder (OCD) are those that effectively block the reuptake of serotonin (5-hydroxytryptamine; 5-HT). In humans, positron emission tomography studies have implicated the orbitofrontal cortex (OFC) in… (More)

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