dbSUPER: a database of super-enhancers in mouse and human genome

@inproceedings{Khan2016dbSUPERAD,
  title={dbSUPER: a database of super-enhancers in mouse and human genome},
  author={Aziz Khan and Xuegong Zhang},
  booktitle={Nucleic Acids Research},
  year={2016}
}
Super-enhancers are clusters of transcriptional enhancers that drive cell-type-specific gene expression and are crucial to cell identity. Many disease-associated sequence variations are enriched in super-enhancer regions of disease-relevant cell types. Thus, super-enhancers can be used as potential biomarkers for disease diagnosis and therapeutics. Current studies have identified super-enhancers in more than 100 cell types and demonstrated their functional importance. However, a centralized… CONTINUE READING
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