dapk1, encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint, is a transcription target of p53

@article{Martoriati2005dapk1EA,
  title={dapk1, encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint, is a transcription target of p53},
  author={Alain Martoriati and Gilles Doumont and Myriam Alcalay and Eric J Bellefroid and Pier Giuseppe Pelicci and J. -C. Marine},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={1461-1466}
}
The p53 tumour suppressor functions as a transcriptional activator, and several p53-inducible genes that play a critical proapoptotic role have been described. Moreover, p53 regulates the expression of various proteins participating in autoregulatory feedback loops, including proteins that negatively control p53 stability (Mdm2 and Pirh2) or modulate stress-induced phosphorylation of p53 on Ser-46 (p53DINP1 or Wip1), a key event for p53-induced apoptosis. Here, we describe a new systematic… CONTINUE READING

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