dSarm/Sarm1 is required for activation of an injury-induced axon death pathway.

@article{Osterloh2012dSarmSarm1IR,
  title={dSarm/Sarm1 is required for activation of an injury-induced axon death pathway.},
  author={Jeannette M Osterloh and Jing Yang and Timothy M. Rooney and A. Nicole Fox and R{\'o}bert Adalbert and E. H. Powell and Amy E. Sheehan and Michelle A. Avery and Rachel Hackett and Mary A Logan and J M Macdonald and Jennifer S. Ziegenfuss and Stefan Milde and Ying-Ju Hou and Carl Nathan and Aihao Ding and R. H. Brown and Laura Conforti and Michael E Coleman and Marc Tessier-Lavigne and Stephan Z{\"u}chner and Marc R. Freeman},
  journal={Science},
  year={2012},
  volume={337 6093},
  pages={481-4}
}
Axonal and synaptic degeneration is a hallmark of peripheral neuropathy, brain injury, and neurodegenerative disease. Axonal degeneration has been proposed to be mediated by an active autodestruction program, akin to apoptotic cell death; however, loss-of-function mutations capable of potently blocking axon self-destruction have not been described. Here, we show that loss of the Drosophila Toll receptor adaptor dSarm (sterile α/Armadillo/Toll-Interleukin receptor homology domain protein) cell… CONTINUE READING
Highly Influential
This paper has highly influenced 21 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 20 times over the past 90 days. VIEW TWEETS
135 Citations
25 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 135 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Similar Papers

Loading similar papers…