dSarm/Sarm1 is required for activation of an injury-induced axon death pathway.

  title={dSarm/Sarm1 is required for activation of an injury-induced axon death pathway.},
  author={Jeannette M Osterloh and Jing Yang and Timothy M. Rooney and A. Nicole Fox and R{\'o}bert Adalbert and E. H. Powell and Amy E. Sheehan and Michelle A. Avery and Rachel Hackett and Mary A Logan and J M Macdonald and Jennifer S. Ziegenfuss and Stefan Milde and Ying-Ju Hou and Carl Nathan and Aihao Ding and R. H. Brown and Laura Conforti and Michael E Coleman and Marc Tessier-Lavigne and Stephan Z{\"u}chner and Marc R. Freeman},
  volume={337 6093},
Axonal and synaptic degeneration is a hallmark of peripheral neuropathy, brain injury, and neurodegenerative disease. Axonal degeneration has been proposed to be mediated by an active autodestruction program, akin to apoptotic cell death; however, loss-of-function mutations capable of potently blocking axon self-destruction have not been described. Here, we show that loss of the Drosophila Toll receptor adaptor dSarm (sterile α/Armadillo/Toll-Interleukin receptor homology domain protein) cell… CONTINUE READING
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