dFMRP and Caprin, translational regulators of synaptic plasticity, control the cell cycle at the Drosophila mid-blastula transition.

@article{Papoulas2010dFMRPAC,
  title={dFMRP and Caprin, translational regulators of synaptic plasticity, control the cell cycle at the Drosophila mid-blastula transition.},
  author={Ophelia Papoulas and Kathryn F Monzo and Greg T. Cantin and Cristian I. Ruse and John R. Yates and Young Hee Ryu and J. C. Sisson},
  journal={Development},
  year={2010},
  volume={137 24},
  pages={4201-9}
}
The molecular mechanisms driving the conserved metazoan developmental shift referred to as the mid-blastula transition (MBT) remain mysterious. Typically, cleavage divisions give way to longer asynchronous cell cycles with the acquisition of a gap phase. In Drosophila, rapid synchronous nuclear divisions must pause at the MBT to allow the formation of a cellular blastoderm through a special form of cytokinesis termed cellularization. Drosophila Fragile X mental retardation protein (dFMRP; FMR1… CONTINUE READING
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