dCLIP: a computational approach for comparative CLIP-seq analyses

  title={dCLIP: a computational approach for comparative CLIP-seq analyses},
  author={Tao Wang and Yang Xie and Guanghua Xiao},
  booktitle={Genome Biology},
Although comparison of RNA-protein interaction profiles across different conditions has become increasingly important to understanding the function of RNA-binding proteins (RBPs), few computational approaches have been developed for quantitative comparison of CLIP-seq datasets. Here, we present an easy-to-use command line tool, dCLIP, for quantitative CLIP-seq comparative analysis. The two-stage method implemented in dCLIP, including a modified MA normalization method and a hidden Markov model… CONTINUE READING
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