d3-Growth hormone receptor polymorphism in acromegaly: effects on metabolic phenotype.

Abstract

OBJECTIVE A common polymorphic variant of the growth hormone receptor (GHR) is because of genomic deletion of exon 3 and has been linked with increased responsiveness to exogenous GH. The impact of this polymorphism in acromegaly, a disease characterized by endogenous excess of GH and partial loss of IGF-I feedback on tumoural GH secretion, is not clear… (More)
DOI: 10.1111/j.1365-2265.2009.03703.x

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