d-pinitol mitigates tumor growth by modulating interleukins and hormones and induces apoptosis in rat breast carcinogenesis through inhibition of NF-κB

@article{Rengarajan2015dpinitolMT,
  title={d-pinitol mitigates tumor growth by modulating interleukins and hormones and induces apoptosis in rat breast carcinogenesis through inhibition of NF-$\kappa$B},
  author={Thamaraiselvan Rengarajan and Natarajan Nandakumar and Peramaiyan Rajendran and Mohanraj Karthik Ganesh and Maruthaiveeran Periyasamy Balasubramanian and I. Nishigaki},
  journal={Journal of Physiology and Biochemistry},
  year={2015},
  volume={71},
  pages={191-204}
}
Breast cancer is the most prevalent malignant neoplasm in the world, and chemoprevention through dietary intervention strategy is an emerging option to reduce the incidence. d-pinitol (DP), a major component of soya bean, possesses attractive biological actions. We have investigated whether d-pinitol have an effect on tumor growth in vivo against 7,12-dimethylbenz(a)anthracene (DMBA)-initiated rat mammary carcinogenesis and investigated its mechanism of action. Tumors were induced in Sprague… Expand
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D-Pinitol, a mono-methylated form of D-chiro-inositol, was identified as an active principle in soy foods and legumes. Mature and dried soybean seeds contain up to 1% D-pinitol. D-pinitol functionsExpand
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