d-chiro-Inositol Ribophostin: A Highly Potent Agonist of d-myo-Inositol 1,4,5-Trisphosphate Receptors: Synthesis and Biological Activities

@article{Mills2020dchiroInositolRA,
  title={d-chiro-Inositol Ribophostin: A Highly Potent Agonist of d-myo-Inositol 1,4,5-Trisphosphate Receptors: Synthesis and Biological Activities},
  author={S. Mills and A. M. Rossi and Vera Konieczny and D. Bakowski and C. Taylor and B. L. Potter},
  journal={Journal of Medicinal Chemistry},
  year={2020},
  volume={63},
  pages={3238 - 3251}
}
  • S. Mills, A. M. Rossi, +3 authors B. L. Potter
  • Published 2020
  • Chemistry, Medicine
  • Journal of Medicinal Chemistry
  • Analogues of the Ca2+-releasing intracellular messenger d-myo-inositol 1,4,5-trisphosphate [1, Ins(1,4,5)P3] are important synthetic targets. Replacement of the α-glucopyranosyl motif in the natural product mimic adenophostin 2 by d-chiro-inositol in d-chiro-inositol adenophostin 4 increased the potency. Similar modification of the non-nucleotide Ins(1,4,5)P3 mimic ribophostin 6 may increase the activity. d-chiro-Inositol ribophostin 10 was synthesized by coupling as building blocks suitably… CONTINUE READING
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