d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties.

@article{Tasinato1995dalphatocopherolIO,
  title={d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties.},
  author={A. Tasinato and D. Boscoboinik and G. M. Bartoli and P. Maroni and A. Azzi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 26},
  pages={
          12190-4
        }
}
  • A. Tasinato, D. Boscoboinik, +2 authors A. Azzi
  • Published 1995
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • d-alpha-Tocopherol, but not d-beta-tocopherol, negatively regulates proliferation of vascular smooth muscle cells at physiological concentrations. d-alpha-Tocopherol inhibits protein kinase C (PKC) activity, whereas d-beta-tocopherol is ineffective. Furthermore d-beta-tocopherol prevents the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol. The negative regulation by d-alpha-tocopherol of PKC activity appears to be the cause and not the effect of smooth muscle cell… CONTINUE READING
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