• Corpus ID: 9349173

d-Methadone is antinociceptive in the rat formalin test.

@article{Shimoyama1997dMethadoneIA,
  title={d-Methadone is antinociceptive in the rat formalin test.},
  author={N Shimoyama and M Shimoyama and Kathryn J. Elliott and Charles E Inturrisi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={283 2},
  pages={
          648-52
        }
}
The l-isomer of methadone possesses opioid activity, whereas the d-isomer is weak or inactive as an opioid. Both d- and l-methadone have been shown to bind to the N-methyl-D-aspartate (NMDA) receptor. To determine whether d-methadone has functional, in vivo NMDA receptor antagonist activity, the antinociceptive effects of d-methadone were evaluated in the rat tail-flick and formalin tests. Cumulative dose-response analysis in the tail-flick test revealed an ED50 value for intrathecal (spinal) l… 
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