d-Limonene-induced male rat-specific nephrotoxicity: evaluation of the association between d-limonene and alpha 2u-globulin.

@article{LehmanMcKeeman1989dLimoneneinducedMR,
  title={d-Limonene-induced male rat-specific nephrotoxicity: evaluation of the association between d-limonene and alpha 2u-globulin.},
  author={Lois D. Lehman-McKeeman and Pablo A. Rodr{\'i}guez and Ray Takigiku and Douglas Caudill and Martin Fey},
  journal={Toxicology and applied pharmacology},
  year={1989},
  volume={99 2},
  pages={250-9}
}
d-Limonene is a naturally occurring monoterpene, which when dosed orally, causes a male rat-specific nephrotoxicity manifested acutely as the exacerbation of protein droplets in proximal tubule cells. Experiments were conducted to examine the retention of [14C]d-limonene in male and female rat kidney, to determine whether d-limonene or one or more of its metabolites associates with the male rat-specific protein, alpha 2u-globulin, and if so, to identify the bound material. The results indicated… CONTINUE READING

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