d-Chiro-inositol and its significance in polycystic ovary syndrome: a systematic review

@article{Galazis2011dChiroinositolAI,
  title={d-Chiro-inositol and its significance in polycystic ovary syndrome: a systematic review},
  author={Nicolas Galazis and Myria Galazi and William U Atiomo},
  journal={Gynecological Endocrinology},
  year={2011},
  volume={27},
  pages={256 - 262}
}
BACKGROUND The pathogenesis of polycystic ovary syndrome (PCOS) has been linked to the development of insulin resistance and hyperinsulinemia. [...] Key MethodMETHODS This was a systematic review done in an Academic Department of Obstetrics and Gynaecology in the UK of all studies published on PCOS and DCI up till May 2010. Patients were women with PCOS receiving DCI or where the relationship between insulin resistance and DCI had been investigated.Expand
Modulatory role of D-chiro-inositol (DCI) on LH and insulin secretion in obese PCOS patients
TLDR
DCI administration is effective in restoring better insulin sensitivity and an improved hormonal pattern in obese hyperinsulinemic PCOS patients, in particular, in hyper insulinemicPCOS patients who have diabetic relatives. Expand
Differential insulin response to myo-inositol administration in obese polycystic ovary syndrome patients
  • A. Genazzani, A. Prati, +6 authors P. Artini
  • Medicine
  • Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2012
TLDR
The hypothesis that MYO administration is more effective in obese patients with high fasting insulin plasma levels is supported, as well as the efficacy on insulin sensitivity and hormonal parameters of 8 weeks treatment with myo-inositol. Expand
The use of inositol(s) isomers in the management of polycystic ovary syndrome: a comprehensive review
  • A. Gateva, V. Unfer, Z. Kamenov
  • Medicine
  • Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2018
TLDR
Myo-inositol monotherapy results more effective in preventing and treating GDM even if a larger cohort of studies is needed to better clarify these results. Expand
Inositols’ Importance in the Improvement of the Endocrine–Metabolic Profile in PCOS
TLDR
The aim of this review is to present the effectiveness of MI and DCI treatment for PCOS symptoms, and is focused on analyzing the use of inositols, taking into account their physiological properties, together with the mechanism of individual PCOS symptom formation. Expand
The menstrual cycle regularization following d-chiro-inositol treatment in PCOS women: a retrospective study
TLDR
The use of d-chiro-inositol treatment is associated to clinical benefits for many women affected by PCOS including the improvement in insulin resistance and menstrual cycle regularity. Expand
POLYCYSTIC OVARY SYNDROME IN ADOLESCENCE: NEW THERAPEUTIC APPROACH WITH INOSITOL AND ALPHA *Maria
Objective: Ovary Syndrome (PCOS), based on Alternative Insulin Sensitizers as Inositol and α natural antioxidant, a Design: Setting: Patients: Intervention: Main outcome measures: therapeuticExpand
Different Effects of Myoinositol plus Folic Acid versus Combined Oral Treatment on Androgen Levels in PCOS Women
TLDR
In PCOS treatment, MYO is observed more effective in reductions of total ovarian volume and AMH levels, and myo-ins effects on anti-Mullerian hormone levels and compare them with those obtained administering COC are examined. Expand
Combining treatment with myo-inositol and D-chiro-inositol (40:1) is effective in restoring ovary function and metabolic balance in PCOS patients
TLDR
New experimental and clinical evidence with MI plus DCI evidenced the suitability of such integrated approach, and provided promising results, further studies need to investigate thoroughly the molecular mechanism and confirm such preliminary data. Expand
Myo-inositol administration positively effects ovulation induction and intrauterine insemination in patients with polycystic ovary syndrome: a prospective, controlled, randomized trial
TLDR
This study shows that MYO should be considered in the treatment of infertile PCOS patients, as MYO administration increases clinical pregnancy rates, lowers total rFSH dose and the duration of the ovulation induction. Expand
Myoinositol combined with alpha-lipoic acid may improve the clinical and endocrine features of polycystic ovary syndrome through an insulin-independent action
  • S. De Cicco, V. Immediata, +8 authors R. Apa
  • Medicine
  • Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2017
TLDR
The combined treatment of ALA and MYO is able to restore the menstrual pattern and to improve the hormonal milieu of PCOS women, even in the absence of apparent changes in insulin metabolism. Expand
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References

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TLDR
UCl(DCI) is inversely correlated with insulin sensitivity in women and is a strong independent predictor of insulin resistance in multivariate models, consistent with a defect in tissue availability or utilization of DCI in PCOS that may contribute to the insulin resistance of the syndrome. Expand
Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome.
TLDR
D-chiro-inositol increases the action of insulin in patients with the polycystic ovary syndrome, thereby improving ovulatory function and decreasing serum androgen concentrations, blood pressure, and plasma triglyceride concentrations. Expand
Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome.
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It is concluded that, in lean women with the polycystic ovary syndrome, D-chiro-inositol reduces circulating insulin, decreases serum androgens, and ameliorates some of the metabolic abnormalities ( increased blood pressure and hypertriglyceridemia) of syndrome X. Expand
Insulin-lowering agents in the management of polycystic ovary syndrome.
TLDR
In a high percentage of patients, treatment with metformin is followed by regularization of menstrual cycle, reduction in hyperandrogenism and in cardiovascular risk factors, and improvement in response to therapies for induction of ovulation. Expand
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TLDR
An overview of PCOS is provided, relevant literature regarding metformin and PCOS related infertility is reviewed, and patient selection prior to instigating treatment is discussed. Expand
Greek hyperinsulinemic women, with or without polycystic ovary syndrome, display altered inositols metabolism.
TLDR
Greek women, with or without PCOS, display increased uCl (DCI) and decreased AUC(DCI-IPG) in association with higher insulin levels but independent of adiposity, which could contribute to insulin resistance and compensatory hyperinsulinemia in Greek women. Expand
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TLDR
The present review will address the rationale for the use of insulin-sensitizing drugs to treat both the short-term and long-term issues in PCOS and emphasize the importance of preventing the long- term risks associated with PCOS, if possible, when choosing a pharmacologic therapy. Expand
Metformin therapy increases insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator in women with polycystic ovary syndrome.
TLDR
In obese women with PCOS, metformin may improve the action of insulin in part by improving insulin-mediated release of DCI-IPG mediators, as evidenced by increased bioactive DCI/AUC released per unit of insulin. Expand
Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17 alpha activity and serum androgens.
TLDR
It is suggested that hyperinsulinemia stimulates ovarian P450c17 alpha activity in nonobese women with PCOS and decreasing serum insulin with metformin reduces ovarian cytochrome P 450c17alpha activity and ameliorates the hyperandrogenism of these women. Expand
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
TLDR
The role of metformin in improving reproductive outcomes in women with PCOS appears to be limited, and there was no evidence that met formin improves live birth rates whether it is used alone or in combination with clomiphene, or when compared with clmiphene. Expand
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