d-Amphetamine-induced hepatotoxicity: possible contribution of catecholamines and hyperthermia to the effect studied in isolated rat hepatocytes

@article{Carvalho1997dAmphetamineinducedHP,
  title={d-Amphetamine-induced hepatotoxicity: possible contribution of catecholamines and hyperthermia to the effect studied in isolated rat hepatocytes},
  author={F{\'e}lix Carvalho and Fernando Remi{\~a}o and Maria Elisa Soares and Rita I L Catarino and Gl{\'o}ria Queiroz and Maria de Lourdes Bastos},
  journal={Archives of Toxicology},
  year={1997},
  volume={71},
  pages={429-436}
}
Amphetamines are indirect-acting sympathomimetic drugs widely abused due to their physical and psychostimulating effects. However, the use of these drugs has been associated with numerous reports of hepatotoxicity. While glutathione depletion induced by amphetamines contributes to the exposure of hepatocytes to oxidative damage, other indirect effects attributed to amphetamines may have a role in cell injury. To examine this possibility, Wistar rats were used for plasma measurements of d… CONTINUE READING

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