d-Amphetamine depresses visual responses in the rat superior colliculus: a possible mechanism for amphetamine-induced decreases in distractibility

@article{Gowan2007dAmphetamineDV,
  title={d-Amphetamine depresses visual responses in the rat superior colliculus: a possible mechanism for amphetamine-induced decreases in distractibility},
  author={Jenny Gowan and V{\'e}ronique Coizet and Ian M. Devonshire and Paul G. Overton},
  journal={Journal of Neural Transmission},
  year={2007},
  volume={115},
  pages={377-387}
}
Amphetamines can enhance sustained attention, and reduce distractibility, in normal subjects and patients with attentional-deficit/hyperactivity disorder (ADHD). Their mechanism of action in this regard is unknown, however one possibility is that the drugs affect the superior colliculus (SC), a structure with a clearly defined role in distractibility. The aim of the present studies was to explore the effect of systemically and locally administered d-amphetamine on visual responses in the… CONTINUE READING