d-Alanine metabolism is essential for growth and biofilm formation of Streptococcus mutans.

@article{Qiu2016dAlanineMI,
  title={d-Alanine metabolism is essential for growth and biofilm formation of Streptococcus mutans.},
  author={Wei Qiu and Xin Zheng and Yu-Quan Wei and Xuedong Zhou and Keying Zhang and Sheng Ling Wang and Leo Cheng and Biao Ren and Xin Xu and Yuan Li and Mingli Li},
  journal={Molecular oral microbiology},
  year={2016},
  volume={31 5},
  pages={435-44}
}
Part of the d-alanine (d-Ala) metabolic pathway in bacteria involves the conversion of l-alanine to d-Ala by alanine racemase and the formation of d-alanyl-d-alanine by d-alanine-d-alanine ligase, the product of which is involved in cell wall peptidoglycan synthesis. At present, drugs that target the metabolic pathway of d-Ala are already in clinical use - e.g. d-cycloserine (DCS) is used as an antibiotic against Mycobacterium tuberculosis. Streptococcus mutans is the main cariogenic bacterium… CONTINUE READING
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