cyclin turnover and nutrient uptake are controlled by a common pathway in yeast

@inproceedings{TOt2007cyclinTA,
  title={cyclin turnover and nutrient uptake are controlled by a common pathway in yeast},
  author={MA TOt and MA Tot and MA Ta},
  year={2007}
}
  • MA TOt, MA Tot, MA Ta
  • Published 2007
Entry into a new cell cycle is triggered by environmental signals at a point called Start in GI phase. A key regulator of this transition step in yeast is the CDC28 kinase together with its short-lived regulatory subunits called Gl-cyclins or CLN proteins. To identify genes involved in Gl-cyclin degradation, we employed a genetic screen by selecting for stable CLNl-13-galactosidase fusion proteins. Surprisingly, one group of mutants was found to be allelic to GRR1, a gene previously described… CONTINUE READING