cutpointr: Improved Estimation and Validation of Optimal Cutpoints in R
@article{Thiele2020cutpointrIE, title={cutpointr: Improved Estimation and Validation of Optimal Cutpoints in R}, author={Christian Thiele and G. Hirschfeld}, journal={arXiv: Computation}, year={2020} }
'Optimal cutpoints' for binary classification tasks are often established by testing which cutpoint yields the best discrimination, for example the Youden index, in a specific sample. This results in 'optimal' cutpoints that are highly variable and systematically overestimate the out-of-sample performance. To address these concerns, the cutpointr package offers robust methods for estimating optimal cutpoints and the out-of-sample performance. The robust methods include bootstrapping and… Expand
6 Citations
The application of deep learning for the classification of correct and incorrect SNP genotypes from whole-genome DNA sequencing pipelines
- Biology, Medicine
- Journal of applied genetics
- 2020
- PDF
Transfer learning enables prediction of CYP2D6 haplotype function
- Biology, Medicine
- PLoS computational biology
- 2020
- 4
- PDF
Establishing a mass spectrometry-based system for rapid detection of SARS-CoV-2 in large clinical sample cohorts
- Medicine
- Nature communications
- 2020
- 4
- PDF
High PD-L1/IDO-2 and PD-L2/IDO-1 Co-Expression Levels Are Associated with Worse Overall Survival in Resected Non-Small Cell Lung Cancer Patients
- Medicine
- Genes
- 2021
- PDF
Optimal cycle thresholds for COVID-19 screening – ROC-based methods highlight between-study differences
- Medicine
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- 2020
- PDF
References
SHOWING 1-10 OF 36 REFERENCES
OptimalCutpoints: An R Package for Selecting Optimal Cutpoints in Diagnostic Tests
- Computer Science
- 2014
- 300
- PDF
GsymPoint: An R Package to Estimate the Generalized Symmetry Point, an Optimal Cut-off Point for Binary Classification in Continuous Diagnostic Tests
- Computer Science
- R J.
- 2017
- 2
- PDF
Estimation of the Youden Index and its associated cutoff point.
- Mathematics, Medicine
- Biometrical journal. Biometrische Zeitschrift
- 2005
- 1,109
- Highly Influential
- PDF
Prediction error estimation: a comparison of resampling methods
- Mathematics, Medicine
- Bioinform.
- 2005
- 842
- PDF
ThresholdROC: Optimum Threshold Estimation Tools for Continuous Diagnostic Tests in R
- Computer Science
- 2017
- 8
- PDF
Bias in sensitivity and specificity caused by data-driven selection of optimal cutoff values: mechanisms, magnitude, and solutions.
- Mathematics, Medicine
- Clinical chemistry
- 2008
- 208
- Highly Influential
- PDF
Internal validation of predictive models: efficiency of some procedures for logistic regression analysis.
- Mathematics, Medicine
- Journal of clinical epidemiology
- 2001
- 1,740
- PDF
pROC: an open-source package for R and S+ to analyze and compare ROC curves
- Computer Science, Medicine
- BMC Bioinformatics
- 2010
- 4,694
- PDF