cis-acting sequences of the rat troponin I slow gene confer tissue- and development-specific transcription in cultured muscle cells as well as fiber type specificity in transgenic mice.

@article{BanerjeeBasu1993cisactingSO,
  title={cis-acting sequences of the rat troponin I slow gene confer tissue- and development-specific transcription in cultured muscle cells as well as fiber type specificity in transgenic mice.},
  author={Sharmila Banerjee-Basu and Andr{\'e}s Buonanno},
  journal={Molecular and cellular biology},
  year={1993},
  volume={13 11},
  pages={7019-28}
}
Transcription of the genes coding for troponin I slow (TnIslow) and other contractile proteins is activated during skeletal muscle differentiation, and their expression is later restricted to specific fiber types during maturation. We have isolated and characterized the rat TnIslow gene in order to begin elucidating its regulation during myogenesis. Transcriptional regulatory regions were delineated by using constructs, containing TnIslow gene sequences driving the expression of the… CONTINUE READING
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