cis-acting ompF mutations that result in OmpR-dependent constitutive expression.

  title={cis-acting ompF mutations that result in OmpR-dependent constitutive expression.},
  author={James M Slauch and Thomas J Silhavy},
  journal={Journal of bacteriology},
  volume={173 13},
OmpR and EnvZ differentially control the transcription of the major outer membrane porin genes, ompF and ompC, in Escherichia coli in response to the osmolarity of the medium. We have previously provided evidence that OmpR works both positively and negatively at the ompF promoter to give the characteristic switch from OmpF to OmpC production with increasing osmolarity. Here, we describe the isolation of cis-acting ompF mutations that affect negative regulation by OmpR by affecting the three… CONTINUE READING

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