cis-acting elements responsible for interleukin-6 inducible C-reactive protein gene expression.

@article{Li1990cisactingER,
  title={cis-acting elements responsible for interleukin-6 inducible C-reactive protein gene expression.},
  author={Schwarz Ping Li and Tina Y Liu and Neil D. Goldman},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 7},
  pages={4136-42}
}
To study the mechanism of induction of human C-reactive protein (CRP) gene expression, we have utilized an in vitro liver cell system to analyze the cis-acting DNA sequences located within the 5'-flanking region of human CRP gene. Stable transfection of human hepatoma cells, PLC/PRF/5, by a CRP gene construct containing the 1 kilobase pair of upstream sequence of the CRP gene demonstrated that this region contained the inducible element(s) which regulated human CRP gene transcription… CONTINUE READING