cis-acting elements in the lytic origin of DNA replication of Epstein-Barr virus.

  title={cis-acting elements in the lytic origin of DNA replication of Epstein-Barr virus.},
  author={Aloys Schepers and Dagmar Pich and Joachim Mankertz and Wolfgang Hammerschmidt},
  journal={Journal of virology},
  volume={67 7},
oriLyt, the cis-acting element of Epstein-Barr virus, mediates viral DNA replication in the lytic phase of the virus's life cycle. Oligonucleotide-directed in vitro mutagenesis of oriLyt plasmids allowed the identification of two noncontiguous components within the complex structure of oriLyt. Both components were indispensable for DNA replication of this origin. The upstream component colocalized with the promoter of the viral BHLF1-encoding gene, and mutants affecting DNA replication affected… CONTINUE READING

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Herpesviral DNA replication: between the known and the unknown

  • W. Hammerschmidt, J. Mankertz
  • Semin. Virol
  • 1991

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