cis-Regulatory Changes in Kit Ligand Expression and Parallel Evolution of Pigmentation in Sticklebacks and Humans

@article{Miller2007cisRegulatoryCI,
  title={cis-Regulatory Changes in Kit Ligand Expression and Parallel Evolution of Pigmentation in Sticklebacks and Humans},
  author={Craig T Miller and Sandra S Beleza and Alex A Pollen and Dolph Schluter and Rick A Kittles and Mark D. Shriver and David M. Kingsley},
  journal={Cell},
  year={2007},
  volume={131},
  pages={1179-1189}
}
Dramatic pigmentation changes have evolved within most vertebrate groups, including fish and humans. Here we use genetic crosses in sticklebacks to investigate the parallel origin of pigmentation changes in natural populations. High-resolution mapping and expression experiments show that light gills and light ventrums map to a divergent regulatory allele of the Kit ligand (Kitlg) gene. The divergent allele reduces expression in gill and skin tissue and is shared by multiple derived freshwater… CONTINUE READING
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