cis-Diamminedichloroplatinum and 5-fluorouracil are potent inducers of the cytokines and natural killer cell activity in vivo and in vitro

@article{Okamoto1998cisDiamminedichloroplatinumA5,
  title={cis-Diamminedichloroplatinum and 5-fluorouracil are potent inducers of the cytokines and natural killer cell activity in vivo and in vitro},
  author={Masato Okamoto and Ryoji Kaji and Hisashi Goda and Go Ohe and Hideo Yoshida and Mitsunobu Sato and Hirofumi Kasatani},
  journal={Cancer Immunology, Immunotherapy},
  year={1998},
  volume={47},
  pages={233-241}
}
It has been reported that certain chemotherapeutic agents exhibit effects that enhance the antitumor host responses in the patients with malignant diseases. In the present study, we investigated whether cis-diamminedichloroplatinum (cisplatin) and 5-fluorouracil (5-FU) may induce cytokines and effector cells with antitumor efficacy in vivo and in vitro. The cultivation of human peripheral blood mononuclear cells (PBMC) in the presence of cisplatin (0–1.0 μg/ml) or 5-FU (0–5.0 μg/ml) resulted in… CONTINUE READING

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