cis-Diamminedichloroplatinum(II)-induced sister chromatid exchange: an indicator of sensitivity and heterogeneity in primary human tumor cell cultures.

@article{Tofilon1986cisDiamminedichloroplatinumIIinduc,
  title={cis-Diamminedichloroplatinum(II)-induced sister chromatid exchange: an indicator of sensitivity and heterogeneity in primary human tumor cell cultures.},
  author={Philip J. Tofilon and Charlotte M. Vines and Fraser L. Baker and Dennis F. Deen and W. A. Brock},
  journal={Cancer research},
  year={1986},
  volume={46 12 Pt 1},
  pages={6156-9}
}
The effect of cis-diamminedichloroplatinum(II) (cPt) on sister chromatid exchange (SCE) induction was determined in 13 human primary tumor cell cultures. Primary cultures were derived from surgical specimens of solid tumors composed of a variety of histologies. Three to 16 days after biopsy, depending on the growth rate, cultures were treated with graded concentrations of cPt for 1 h and the SCE assay was performed. SCE dose-response curves (SCEs induced per chromosome versus cPt concentration… CONTINUE READING

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