cis-Acting elements that control expression of the master virulence regulatory gene atxA in Bacillus anthracis.

@article{Dale2012cisActingET,
  title={cis-Acting elements that control expression of the master virulence regulatory gene atxA in Bacillus anthracis.},
  author={Jennifer L. Dale and Malik J. Raynor and Prabhat Dwivedi and Theresa M Koehler},
  journal={Journal of bacteriology},
  year={2012},
  volume={194 15},
  pages={4069-79}
}
Transcription of the Bacillus anthracis structural genes for the anthrax toxin proteins and biosynthetic operon for capsule is positively regulated by AtxA, a transcription regulator with unique properties. Consistent with the role of atxA in virulence factor expression, a B. anthracis atxA-null mutant is avirulent in a murine model for anthrax. In culture, multiple signals impact atxA transcript levels, and the timing and steady-state level of atxA expression are critical for optimal toxin and… CONTINUE READING
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