cis-Acting DNA from Fission Yeast Centromeres Mediates Histone H3 Methylation and Recruitment of Silencing Factors and Cohesin to an Ectopic Site

@article{Partridge2002cisActingDF,
  title={cis-Acting DNA from Fission Yeast Centromeres Mediates Histone H3 Methylation and Recruitment of Silencing Factors and Cohesin to an Ectopic Site},
  author={Janet F. Partridge and Kristin S.C Scott and Andrew J. Bannister and Tony Kouzarides and Robin C. Allshire},
  journal={Current Biology},
  year={2002},
  volume={12},
  pages={1652-1660}
}
BACKGROUND Metazoan centromeres are generally composed of large repetitive DNA structures packaged in heterochromatin. Similarly, fission yeast centromeres contain large inverted repeats and two distinct silenced domains that are both required for centromere function. The central domain is flanked by outer repetitive elements coated in histone H3 methylated on lysine 9 and bound by conserved heterochromatin proteins. This centromeric heterochromatin is required for cohesion between sister… CONTINUE READING
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