circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a

  title={circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a},
  author={Rongfang He and Peng Liu and Xiaoming Xie and Yujuan Zhou and Qianjin Liao and Wei Xiong and Xiaoling Li and Guiyuan Li and Zhaoyang Zeng and Hailin Tang},
  booktitle={Journal of experimental & clinical cancer research : CR},
BACKGROUD Accumulating evidences indicate that circular RNAs (circRNAs), a class of non-coding RNAs, play important roles in tumorigenesis. However, the function of circRNAs in triple negative breast cancer (TNBC) is largely unknown. METHODS We performed circRNA microarrays to identify circRNAs that are aberrantly expressed in TNBC cell lines. Expression levels of a significantly upregulated circRNA, circGFRA1, was detected by quantitative real-time PCR (qRT-PCR) in TNBC cell lines and… CONTINUE READING
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