ciRS-7 exonic sequence is embedded in a long non-coding RNA locus

@inproceedings{Barrett2017ciRS7ES,
  title={ciRS-7 exonic sequence is embedded in a long non-coding RNA locus},
  author={Steven P Barrett and Kevin R. Parker and Caroline Horn and Miguel A. Mata and Julia Salzman},
  booktitle={PLoS genetics},
  year={2017}
}
ciRS-7 is an intensely studied, highly expressed and conserved circRNA. Essentially nothing is known about its biogenesis, including the location of its promoter. A prevailing assumption has been that ciRS-7 is an exceptional circRNA because it is transcribed from a locus lacking any mature linear RNA transcripts of the same sense. To study the biogenesis of ciRS-7, we developed an algorithm to define its promoter and predicted that the human ciRS-7 promoter coincides with that of the long non… CONTINUE READING
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