cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes

@article{Davidson2003cdx4MF,
  title={cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes},
  author={Alan J. W. Davidson and Patricia Ernst and Yuan Wang and Marcus P. S. Dekens and Paul Kingsley and James Palis and S Stanley J. Korsmeyer and George Q. Daley and Leonard I. Zon},
  journal={Nature},
  year={2003},
  volume={425},
  pages={300-306}
}
Organogenesis is dependent on the formation of distinct cell types within the embryo. Important to this process are the hox genes, which are believed to confer positional identities to cells along the anteroposterior axis. Here, we have identified the caudal-related gene cdx4 as the locus mutated in kugelig (kgg), a zebrafish mutant with an early defect in haematopoiesis that is associated with abnormal anteroposterior patterning and aberrant hox gene expression. The blood deficiency in kgg… CONTINUE READING