cdk-7 Is required for mRNA transcription and cell cycle progression in Caenorhabditis elegans embryos.

@article{Wallenfang2002cdk7IR,
  title={cdk-7 Is required for mRNA transcription and cell cycle progression in Caenorhabditis elegans embryos.},
  author={Matthew R. Wallenfang and Geraldine Seydoux},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 8},
  pages={5527-32}
}
CDK7 is a cyclin-dependent kinase proposed to function in two essential cellular processes: transcription and cell cycle regulation. CDK7 is the kinase subunit of the general transcription factor TFIIH that phosphorylates the C-terminal domain (CTD) of RNA polymerase II, and has been shown to be broadly required for transcription in Saccharomyces cerevisiae. CDK7 can also phosphorylate CDKs that promote cell cycle progression, and has been shown to function as a CDK-activating kinase (CAK) in… CONTINUE READING