cdc2 phosphorylation of threonine 124 activates the origin-unwinding functions of simian virus 40 T antigen.

Abstract

Phosphorylation of simian virus 40 (SV40) T antigen on threonine 124 activates viral DNA replication in vivo and in vitro. We have manipulated the modification of T-antigen residue 124 both genetically and biochemically and have investigated individual replication functions of T antigen under conditions suitable for in vitro DNA replication. We find that… (More)

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@article{McVey1993cdc2PO, title={cdc2 phosphorylation of threonine 124 activates the origin-unwinding functions of simian virus 40 T antigen.}, author={Duncan L McVey and S. Ray and Y a Gluzman and Lee R Berger and Alan G Wildeman and Daniel R. Marshak and P Tegtmeyer}, journal={Journal of virology}, year={1993}, volume={67 9}, pages={5206-15} }