cdc18+ regulates initiation of DNA replication in Schizosaccharomyces pombe.

  title={cdc18+ regulates initiation of DNA replication in Schizosaccharomyces pombe.},
  author={Marco Muzi Falconi and Grant W Brown and Thomas B Kelly},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 4},
In the fission yeast Schizosaccharomyces pombe the cdc18'+gene is required both for initiation of DNA replication and for coupling mitosis to the completion of S phase. Cells lacking Cdc18 fail to enter S phase but still undergo nuclear division. Expression of cdc18+ is sufficient to drive a G1-arrested cdc10ts mutant into the S phase of the cell cycle, indicating that cdc18+ represents a critical link between passage through START and the initiation of DNA replication. Here we show that Cdcl8… CONTINUE READING
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