cardiotoxicity of Oral Methadone as an Analgesic— recommendations for safe Use


Once used only as third-line therapy in the management of chronic pain states, methadone is now being used as firstand second-line therapy. Most risks and the stigma associated with methadone use have been known for years. Only over the past decade or so have the unique pharmacokinetic-pharmacodynamic properties and methods for conversion from other opioids… (More)


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