cRGD-functionalized, DOX-conjugated, and ⁶⁴Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging.

@article{Yang2011cRGDfunctionalizedDA,
  title={cRGD-functionalized, DOX-conjugated, and ⁶⁴Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging.},
  author={Xiaoqiang Yang and Hao Hong and Jamison J Grailer and Ian J. Rowland and Alireza Javadi and Samuel A. Hurley and Yuling Xiao and Yunan Yang and Yin Zhang and Robert Jerry Nickles and Weibo Cai and Douglas A. Steeber and Shaoqin Gong},
  journal={Biomaterials},
  year={2011},
  volume={32 17},
  pages={4151-60}
}
Multifunctional and water-soluble superparamagnetic iron oxide (SPIO) nanocarriers were developed for targeted drug delivery and positron emission tomography/magnetic resonance imaging (PET/MRI) dual-modality imaging of tumors with integrin α(v)β₃ expression. An anticancer drug was conjugated onto the PEGylated SPIO nanocarriers via pH-sensitive bonds. Tumor-targeting ligands, cyclo(Arg-Gly-Asp-d-Phe-Cys) (c(RGDfC)) peptides, and PET ⁶⁴Cu chelators, macrocyclic 1,4,7-triazacyclononane-N, N', N… CONTINUE READING