cPRA Increases With DQA, DPA, and DPB Unacceptable Antigens in the Canadian cPRA Calculator

@inproceedings{Tinckam2015cPRAIW,
  title={cPRA Increases With DQA, DPA, and DPB Unacceptable Antigens in the Canadian cPRA Calculator},
  author={Kathryn J Tinckam and Robert Stefan Liwski and Denise Pochinco and M. Mousseau and Alicia Grattan and Peter H. Nickerson and Patricia Campbell},
  booktitle={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2015}
}
A calculated panel reactive antibody (cPRA) estimates the percentage of donors with unacceptable antigens (UA) for a recipient. cPRA may be underestimated in transplant candidates with UA to DQA, DPA, and DPB if these are not included in the calculation program. To serve the National Canadian Transplant Programs, a cPRA calculator was developed with complete molecular typing for all donors at HLA-A, B, C, DRB1, DRB3/4/5, DQA1, DQB1, DPA1, and DPB1, all resolved to serologic equivalents. The… CONTINUE READING