cIAP1, cIAP2, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation.

@article{Jin2009cIAP1CA,
  title={cIAP1, cIAP2, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation.},
  author={Hyung-seung Jin and Dong-Hee Lee and Dong-Hwan Kim and Ji-Hye Chung and Seul-Ji Lee and Tae Ho Lee},
  journal={Cancer research},
  year={2009},
  volume={69 5},
  pages={1782-91}
}
Various genotoxic agents cause monoubiquitination of NEMO/IKKgamma-the regulatory subunit of IkappaB kinase (IKK) complex-in the nucleus. Ubiquitinated NEMO exits from the nucleus and forms a complex with the IKK catalytic subunits IKKalpha and IKKbeta, resulting in IKK activation and, ultimately, nuclear factor-kappaB (NF-kappaB) activation. Thus, NEMO ubiquitination is a prerequisite for IKK-dependent activation of NF-kappaB. However, the IKK activation mechanism is unknown and the NEMO… CONTINUE READING

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