cGMP signals mainly through cAMP kinase in permeabilized murine aorta.

@article{Wrner2007cGMPSM,
  title={cGMP signals mainly through cAMP kinase in permeabilized murine aorta.},
  author={Ren{\'e} W{\"o}rner and Robert Lukowski and Franz Hofmann and J{\"o}rg Werner Wegener},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={292 1},
  pages={H237-44}
}
GMP affects vascular tone by multiple mechanisms, including inhibition of the Rho/Rho kinase-mediated Ca(2+) sensitization, a process identified as Ca(2+) desensitization. Ca(2+) desensitization is mediated probably by both cGMP- and cAMP-dependent protein kinases (cGKI and PKA). We investigate to which extent Ca(2+) desensitization is initiated by cGKI and PKA. cGMP/cAMP-induced relaxation was studied at constant [Ca(2+)] in permeabilized aortas from wild-type and cGKI-deficient mice. [Ca(2… CONTINUE READING