cGMP produced in response to ANP and CNP regulates proliferation and differentiation of osteoblastic cells.

@article{Hagiwara1996cGMPPI,
  title={cGMP produced in response to ANP and CNP regulates proliferation and differentiation of osteoblastic cells.},
  author={H Hagiwara and Akio Inoue and Akihiro Yamaguchi and Satoshi Yokose and Mitsuko Furuya and Seiya Tanaka and Shunichi Hirose},
  journal={The American journal of physiology},
  year={1996},
  volume={270 5 Pt 1},
  pages={
          C1311-8
        }
}
The effects of natriuretic peptides on the proliferation and differentiation of osteoblast-like cells from rat calvariae were examined. Natriuretic peptides are physiological agonists that activate receptor guanylate cyclases, namely, natriuretic peptide receptor (NPR)-A and NPR-B. Exposure of cells to atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) resulted in large increases in the rate of intracellular production of guanosine 3',5'-cyclic monophosphate (cGMP). Moreover… CONTINUE READING

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Endothelins inhibit the mineralization of osteoblastic MC3T3-E1 cells through the A-type endothelin receptor.

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  • 1998
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