cGMP inhibits the activity of single calcium channels in embryonic chick heart cells.

  title={cGMP inhibits the activity of single calcium channels in embryonic chick heart cells.},
  author={Noritsugu Tohse and Nick Sperelakis},
  journal={Circulation research},
  volume={69 2},
Effects of cGMP on the slow (L-type) Ca2+ channels of cultured chick embryonic cardiomyocytes were investigated by a cell-attached patch-clamp method. Superfusion of the single cells with 8-bromo-cGMP, a membrane-permeable derivative of cGMP, inhibited the single-channel activity. The cyclic nucleotide decreased, in a concentration-dependent manner, the ensemble averaged currents obtained from multichannel patches. 8-Bromo-cGMP (1 mM) completely abolished the currents (n = 8), whereas 0.1 mM… CONTINUE READING

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