cGMP facilitates calcium current via cGMP-dependent protein kinase in isolated rabbit ventricular myocytes

@article{Han1998cGMPFC,
  title={cGMP facilitates calcium current via cGMP-dependent protein kinase in isolated rabbit ventricular myocytes},
  author={Jennifer Han and Euiyong Kim and Suk Ho Lee and Seokho Yoo and Won-Kyung Ho and Yung E. Earm},
  journal={Pfl{\"u}gers Archiv},
  year={1998},
  volume={435},
  pages={388-393}
}
 The effect of guanosine 3′,5′-cyclic monophosphate (cGMP) on L-type Ca current (I Ca) was investigated in a study of rabbit ventricular myocytes using the whole-cell patch-clamp technique. Intracellular application of cGMP (100 μM) increased I Ca in the absence of isoprenaline or forskolin. 8-Bromo-cGMP (100 μM) and 8-(4-chlorophenylthio)-cGMP (8-pCPT-cGMP, 400 μM), relatively specific stimulators of cGMP-dependent protein kinase (cGMP-PK), also increased I Ca. The stimulatory effect of 8-pCPT… CONTINUE READING
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