cGMP-dependent relaxation of smooth muscle is coupled with the change in the phosphorylation of myosin phosphatase.

Abstract

Nitric oxide/cGMP pathway induces vasodilatation, yet the underlying mechanism is obscure. In the present study, we studied the mechanism of cGMP-induced relaxation of the smooth muscle contractile apparatus using permeabilized rabbit femoral arterial smooth muscle. 8-Br-cGMP-induced relaxation was accompanied with a decrease in myosin light chain (MLC… (More)

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@article{Nakamura2007cGMPdependentRO, title={cGMP-dependent relaxation of smooth muscle is coupled with the change in the phosphorylation of myosin phosphatase.}, author={Kensei Nakamura and Y Koga and Hiroyasu Sakai and Kazuaki Homma and Mitsuo Ikebe}, journal={Circulation research}, year={2007}, volume={101 7}, pages={712-22} }