cGMP-dependent protein kinase protects cGMP from hydrolysis by phosphodiesterase-5.

  title={cGMP-dependent protein kinase protects cGMP from hydrolysis by phosphodiesterase-5.},
  author={Jun Kotera and Kennard A Grimes and Jackie D. Corbin and Sharron H. Francis},
  journal={The Biochemical journal},
  volume={372 Pt 2},
The physiological effects of cGMP are largely determined by the activities of intracellular receptors, including cGMP-dependent protein kinase (PKG) and cGMP-binding cyclic nucleotide phosphodiesterases (PDEs), and the distribution of cGMP among these receptors dictates activity of the signalling pathway. In the present study, the effects of PKG-Ialpha or PKG-Ibeta on the rate of cGMP hydrolysis by the isolated PDE5 catalytic domain were examined. PKG-Ialpha strongly inhibited cGMP hydrolysis… CONTINUE READING


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