cGMP-dependent protein kinase inhibits serum-response element-dependent transcription by inhibiting rho activation and functions.

@article{Gudi2002cGMPdependentPK,
  title={cGMP-dependent protein kinase inhibits serum-response element-dependent transcription by inhibiting rho activation and functions.},
  author={Tanima Gudi and Jeffrey C Chen and Darren E. Casteel and Tammy M. Seasholtz and Gerry R. Boss and Renate B Pilz},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 40},
  pages={37382-93}
}
RhoA, in its active GTP-bound form, stimulates transcription through activation of the serum-response factor (SRF). We found that cGMP inhibited serum-induced Rho.GTP loading and transcriptional activation of SRF-dependent reporter genes in smooth muscle and glial cells in a cGMP-dependent protein kinase (G-kinase)-dependent fashion. Serum stimulation of the SRF target gene vinculin was also blocked by cGMP/G-kinase. G-kinase activation inhibited SRF-dependent transcription induced by upstream… CONTINUE READING
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