cGMP and glutathione-conjugate transport in human erythrocytes.

  title={cGMP and glutathione-conjugate transport in human erythrocytes.},
  author={Antonios Klokouzas and C Wu and Hendrik W van Veen and Margery A. Barrand and Stephen Hladky},
  journal={European journal of biochemistry},
  volume={270 18},
The nature of cGMP transport in human erythrocytes, its relationship to glutathione conjugate transport, and possible mediation by multidrug resistance-associated proteins (MRPs) have been investigated. MRP1, MRP4 and MRP5 are detected in immunoblotting studies with erythrocytes. MRP1 and MRP5 are also detected in multidrug resistant COR-L23/R and MOR/R cells but at greatly reduced levels in the parent, drug sensitive COR-L23/P cells. MRP4 is detected in MOR/R but not COR-L23/R cells. Uptake of… CONTINUE READING