cGMP activates a pH-sensitive leak K+ current in the presumed cholinergic neuron of basal forebrain.

@article{Toyoda2008cGMPAA,
  title={cGMP activates a pH-sensitive leak K+ current in the presumed cholinergic neuron of basal forebrain.},
  author={Hiroki Toyoda and Mitsuru Saito and Hajime Sato and Yoshie Dempo and Atsuko Ohashi and Toshihiro Hirai and Yoshinobu Maeda and Takeshi Kaneko and Youngnam Kang},
  journal={Journal of neurophysiology},
  year={2008},
  volume={99 5},
  pages={2126-33}
}
In an earlier study, we demonstrated that nitric oxide (NO) causes the long-lasting membrane hyperpolarization in the presumed basal forebrain cholinergic (BFC) neurons by cGMP-PKG-dependent activation of leak K+ currents in slice preparations. In the present study, we investigated the ionic mechanisms underlying the long-lasting membrane hyperpolarization with special interest in the pH sensitivity because 8-Br-cGMP-induced K+ current displayed Goldman-Hodgkin-Katz rectification characteristic… CONTINUE READING